Best Warframe for Alchemy (2026)
Last Updated on September 30, 2026
Follie is the first pick because Shadowgraph hands you three Amphors on a 30-second cooldown, and Amphors are the whole mission. Vauban, Mag and Nova drag enemies to the Crucible so the carry stays short, and Volt and Saryn keep the Amphor supply high. Kill speed sets your pace: this mode spawns more enemies than a normal endless run.
Researched September 29, 2026, current through Update 44 (Iceblade of Narin). Picks need two independent sources; anything we could only confirm once is left out.
| Frame | Why | Build focus |
|---|---|---|
| Follie | Shadowgraph can make three Amphors of random element on a 30-second cooldown, so you are never waiting on a drop. | range high |
| Vauban | Bastille collapses into a vortex that pulls enemies in, and the Minelayer orb drags them from a distance. | duration high, range high |
| Mag | Pull drags a whole wave to you in one cast. | range high |
| Nova | Wormhole sends allies and enemies straight to the exit portal, so a portal set at the Crucible turns the room into a short walk. | efficiency high, range high |
| Volt | Speed cuts the run between the kill spot and the Crucible, which matters when an Amphor only lasts about a minute. | balanced |
| Saryn | Spores and Miasma kill whole rooms at once, and more kills means more Amphors on the floor at the same moment. | strength high, range high |
Table of Contents
How the mission works
- Alchemy is an endless mission at Albrecht's Laboratories (Cambire, Deimos), unlocked by the Whispers in the Walls quest. Enemies drop Amphors of a primary element (Heat, Cold, Electricity or Toxin).
- Alt-fire throws an Amphor. It explodes in a 10 meter radius, hits for 90 percent of an enemy's max health, and fills the Crucible without line of sight. Amphors sit on the ground for about a minute.
- Fill two primary elements to make a secondary one (Blast, Corrosive, Gas, Magnetic, Radiation or Viral). Then keep the pressure bar inside its bracket by shooting marked Distressed Pipes.
- Rewards run AABC, one rotation per finished Crucible. Mandonel parts and Tennokai mods sit in the later rotations.
The picks
1. Follie
Shadowgraph can make three Amphors of random element on a 30-second cooldown, so you are never waiting on a drop. Her inkblot passive slows enemies and drops orbs, which pays for the casts.
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2. Vauban
Bastille collapses into a vortex that pulls enemies in, and the Minelayer orb drags them from a distance. Stack a wave beside the Crucible, then kill it there.
WARFRAMEWARFRAMEWARFRAMEWARFRAME3. Mag
Pull drags a whole wave to you in one cast. Park yourself next to the Crucible and every Amphor drops within a few steps of it.
WARFRAMEWARFRAMEWARFRAMEWARFRAME4. Nova
Wormhole sends allies and enemies straight to the exit portal, so a portal set at the Crucible turns the room into a short walk. Escape Velocity adds speed after each hop.
NovaWARFRAMEWARFRAMEWARFRAME5. Volt
Speed cuts the run between the kill spot and the Crucible, which matters when an Amphor only lasts about a minute.
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VoltWARFRAMEWARFRAMEWARFRAME6. Saryn
Spores and Miasma kill whole rooms at once, and more kills means more Amphors on the floor at the same moment.
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SET: WARFRAMEWARFRAMETips that save runs
- Match the drop color to what the Crucible asks for. A wrong-color Amphor can still be thrown at enemies for that element's damage.
- Drag enemies next to the Crucible before you kill them. Amphors drop where they die, so a short carry saves the most time.
- Amphor blasts need no line of sight to fill the Crucible, so you can throw from around a corner.
- Do not stockpile Amphors. They vanish after about a minute.
- During conversion, shoot a Distressed Pipe only when the bar leaves its bracket. The bracket moves once, at 50 percent. Pipes sit in the Crucible room or the one next to it.
Mistakes that waste runs
- Shooting pipes on reflex. Conversion slows to a crawl when the bar sits outside its bracket, so vent only when it drifts.
- Leaving after the first Crucible. The better drops come in the later rotations.
- Only checking the Crucible room for pipes and missing the ones next door.
Honorable mentions
- Any frame that clears a room fast works here. The mission spawns more enemies than usual, so kill speed is your Amphor supply.