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Best Warframe for Exterminate Missions

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Last Updated on September 9, 2026

Saryn wins Exterminate. Spores chain-kill the room through walls, no aiming needed. Mesa’s Peacemaker is the safer runner-up, close to a near-AFK clear.

Frame	Why it works	Build focus
Saryn	Spores chain-kill the room through walls once popped	Range + Strength
Mesa	Peacemaker auto-headshots every visible enemy	Strength + Duration
Volt	Discharge chains lightning and refunds energy per kill	Range + Strength
Gauss	80 m/s Redline sprint procs burn and blast on contact	Strength
Octavia	Mallet and Resonator kill on the beat as she runs past	Strength (max)

SarynRoom nuke

MesaHeadshot bot

VoltSpeed nuke

GaussSprint clear

OctaviaBeat killer

Table of Contents

Best weapons for Exterminate

ToridChains gas clouds

Kuva ZarrBomblet chain kill

Ignis WraithFlame cone punch-through

Kuva NukorChains between enemies

Weapon	Why
Torid	Incarnon gas clouds chain through a room without aiming for heads.
Kuva Zarr	Shells split into six bomblets that chain-detonate a whole cluster.
Ignis Wraith	Flame cone with punch-through hits everyone in a line, even through thin walls.
Kuva Nukor	Beam auto-chains between enemies and primes viral or heat fast.

Saryn: room nuke

Spores spreads corrosive and viral damage to everything nearby, and popping one drops the whole cluster, walls included.

Strength: highDuration: highEfficiency: midRange: max

Overextended

+90% Ability Range

-60% Ability Strength

WARFRAME

Blind Rage

+99% Ability Strength

-55% Ability Efficiency

WARFRAME

Archon Continuity

+55% Ability Duration

Abilities that inflict a Toxin status effect will also apply a Corrosive status effect.

WARFRAME

Corrosive Projection

Enemies lose -18% Armor

AURA

Stretch

+45% Ability Range

WARFRAME

A cheap Cetus-bounty Saryn clears tiles as well as Prime does.

Mesa: headshot bot

Peacemaker auto-locks onto every enemy in the room and headshots them, and Shatter Shield keeps her immune the whole time.

Strength: highDuration: highEfficiency: midRange: low

Umbral Intensify

+44% Ability Strength

+11% Tau Resistance

Enhance mods in this set.

SET: WARFRAME

Narrow Minded

+99% Ability Duration

-66% Ability Range

WARFRAME

Mesa's Waltz

Peacemaker Augment: Mesa can move at 50% Speed while using Peacemaker.

Mesa

Adaptation

When Damaged: +10% Resistance to that Damage Type for 20s. Stacks up to 90%.

WARFRAME

Primed Flow

+185% Energy Max

WARFRAME

Non-Prime Mesa already one-shots exterminate mobs, no Prime needed. Mesa’s Waltz adds movement so you’re not planted in one spot.

Volt: speed nuke

Discharge chains lightning through the room and refunds energy on every kill, so you can spam it nonstop.

Strength: highDuration: lowEfficiency: midRange: max

Overextended

+90% Ability Range

-60% Ability Strength

WARFRAME

Blind Rage

+99% Ability Strength

-55% Ability Efficiency

WARFRAME

Natural Talent

+50% Casting Speed

WARFRAME

Streamline

+30% Ability Efficiency

WARFRAME

Volt costs next to nothing on the market and barely needs Forma to run well.

Gauss: sprint and shoot

Redline turns him into an 80 m/s blur that procs burn and blast on everything he passes.

Strength: highDuration: lowEfficiency: midRange: mid

Rush

+30% Sprint Speed

WARFRAME

Speed Drift

+12% Sprint Speed

+15% Casting Speed

WARFRAME

Intensify

+30% Ability Strength

WARFRAME

Thermal Transfer

Thermal Sunder Augment: Allies in range gain 75% bonus Elemental Damage for 30s.

Gauss

Gauss comes free from Vox Solaris bounties, and he outruns most spawn timers without even trying.

Octavia: kills on the beat

Mallet rides along on Resonator and detonates on the beat, deleting everything in her path.

Strength: maxDuration: midEfficiency: midRange: mid

Blind Rage

+99% Ability Strength

-55% Ability Efficiency

WARFRAME

Transient Fortitude

+55% Ability Strength

-27.5% Ability Duration

WARFRAME

Narrow Minded

+99% Ability Duration

-66% Ability Range

WARFRAME

Continuity

+30% Ability Duration

WARFRAME

Octavia’s quest grind takes a while, so most players run Volt or Gauss until she’s built.

Honorable mentions

Equinox (Maim): melts quick low-level speedrun clears
Wukong (Prime): fast, tanky carry, any weapon
Nova: Molecular Prime speeds your actions
Ember: budget pick, no longer top-tier

Best weapons for Exterminate

Saryn: room nuke

Mesa: headshot bot

Volt: speed nuke

Gauss: sprint and shoot

Octavia: kills on the beat

Honorable mentions

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